Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine

Guan‐Sheng Jiao, Lynne Cregar, Jinzhi Wang, +7

Proceedings of the National Academy of Sciences

Chemical BiologyMedicinal ChemistryPharmaceutical ChemistryDrug TargetBiochemistry +13

High-Throughput Screening of Enzyme Inhibitors: Automatic Determination of Tight-Binding Inhibition Constants

Petr Kuzmič, Steve Sideris, Lynne Cregar, +3

Analytical Biochemistry

Molecular DockingDrug TargetBiochemistryTight-binding Inhibition ConstantsMedicine +7

High-Throughput Screening of Enzyme Inhibitors: Simultaneous Determination of Tight-Binding Inhibition Constants and Enzyme Concentration

Petr Kuzmič, Kyle Elrod, Lynne Cregar, +3

Analytical Biochemistry

Medicinal ChemistryDrug TargetBiochemistryTight-binding Inhibition ConstantsMedicine +10

Optimization of a screening lead for factor VIIa/TF

Wendy B. Young, Aleksandr Kolesnikov, Roopa Rai, +8

Bioorganic & Medicinal Chemistry Letters

Translational MedicineHit IdentificationScreening LeadMedicineLead Identification +6

Neutrophil Myeloperoxidase Is a Potent and Selective Inhibitor of Mast Cell Tryptase

Lynne Cregar, Kyle Elrod, Daun Putnam, +1

Archives of Biochemistry and Biophysics

InflammationAllergyGranulocyteMast Cell DisorderImmunology +9

Dibasic inhibitors of human mast cell tryptase. Part 2: Structure–activity relationships and requirements for potent activity

Kenneth D. Rice, Vivian R. Wang, Anthony R. Gangloff, +8

Bioorganic & Medicinal Chemistry Letters

AllergyMedicineMast Cell DisorderDibasic InhibitorsMechanism Of Action +6

Cationic polyamines inhibit anthrax lethal factor protease

Mark E. Goldman, Lynne Cregar, Dominique T. Nguyen, +3

BMC Pharmacology

Dibasic inhibitors of human mast cell tryptase. Part 1: Synthesis and optimization of a novel class of inhibitors

Kenneth D. Rice, Anthony R. Gangloff, Elaine Y. Kuo, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAllergyMedicineNatural SciencesMast Cell Disorder +10

Mixed‐type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides

Petr Kuzmič, Lynne Cregar, Sherri Z. Millis, +1

FEBS Journal

Guanidinylated 2,5-dideoxystreptamine derivatives as anthrax lethal factor inhibitors

Guan‐Sheng Jiao, Lynne Cregar, Mark E. Goldman, +2

Bioorganic & Medicinal Chemistry Letters

Medicinal Chemistry2,5-Dideoxystreptamine DerivativesMedicineMechanism Of ActionPharmacotherapy +3