GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity

Riley E. Perszyk, John O. DiRaddo, Katie L. Strong, +10

Molecular Pharmacology

Structural Determinants and Mechanism of Action of a GluN2C-selective NMDA Receptor Positive Allosteric Modulator

Alpa Khatri, Pieter B. Burger, Sharon A. Swanger, +7

Molecular Pharmacology

Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells

Subhrajit Bhattacharya, Alpa Khatri, Sharon A. Swanger, +5

Neuron

NeurophysiologyDominant Receptor PopulationNeurotransmitterUnique Single-channel PropertiesNeuroscience +8

Potentiation of GluN2C/D NMDA Receptor Subtypes in the Amygdala Facilitates the Retention of Fear and Extinction Learning in Mice

Kevin K. Ogden, Alpa Khatri, Stephen F. Traynelis, +1

Neuropsychopharmacology

Amygdala FacilitatesNeurobiological MechanismMolecular NeurosciencePsychiatryBehavioral Neuroscience +10

Design, Synthesis, and Structure–Activity Relationship of a Novel Series of GluN2C-Selective Potentiators

Sommer S. Zimmerman, Alpa Khatri, Ethel C. Garnier‐Amblard, +6

Journal of Medicinal Chemistry

Structure–activity RelationshipSynaptic TransmissionChemistryPharmaceutical ChemistryMolecular Pharmacology +14

Structure–Activity Relationships and Pharmacophore Model of a Noncompetitive Pyrazoline Containing Class of GluN2C/GluN2D Selective Antagonists

Timothy M. Acker, Alpa Khatri, Katie M. Vance, +5

Journal of Medicinal Chemistry

Glun2c/glun2d Selective AntagonistsPharmacotherapyStrong Subunit SelectivityStructure–activity RelationshipsPharmacodynamic Modeling +18

Biased modulators of NMDA receptors control channel opening and ion selectivity

Riley E. Perszyk, Sharon A. Swanger, Chris Shelley, +14

Nature Chemical Biology

Ion SelectivityChannel OpeningMedicineSynaptic TransmissionPhysiology +7

Structural Rearrangements in Loop F of the GABA Receptor Signal Ligand Binding, Not Channel Activation

Alpa Khatri, Anna Sedelnikova, David S. Weiss

Biophysical Journal

Signal TransductionMolecular PhysiologyBiochemistryFunctional SelectivityNatural Sciences +11

Site-Specific Fluorescence Reveals Distinct Structural Changes Induced in the Human ρ1 GABA Receptor by Inhibitory Neurosteroids

Ping Li, Alpa Khatri, John Bracamontes, +3

Molecular Pharmacology