NMDA Receptors in the Central Nervous System

Kasper B. Hansen, Feng Yi, Riley E. Perszyk, +2

Methods in molecular biology

NeurophysiologyNmda ReceptorsNeuropeptide ReceptorNeuropharmacologyNeurology +6

GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity

Riley E. Perszyk, John O. DiRaddo, Katie L. Strong, +10

Molecular Pharmacology

Structural Determinants of Agonist Efficacy at the Glutamate Binding Site of N-Methyl-d-Aspartate Receptors

Kasper B. Hansen, N. Tajima, Rune Risgaard, +7

Molecular Pharmacology

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups

Riley E. Perszyk, Brooke M. Katzman, Hirofumi Kusumoto, +8

eLife

NeurotransmitterMolecular BiologyNeurotransmissionMethyl GroupsBinding Site +17

Biased modulators of NMDA receptors control channel opening and ion selectivity

Riley E. Perszyk, Sharon A. Swanger, Chris Shelley, +14

Nature Chemical Biology

Ion SelectivityChannel OpeningMedicineSynaptic TransmissionPhysiology +7

Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors

Lauren M. DePoy, Riley E. Perszyk, Kelsey S. Zimmermann, +2

Frontiers in Pharmacology

Substance UseNeurotransmitterSocial SciencesOrbitofrontal CortexDeep-layer Opfc +15

Three-dimensional missense tolerance ratio analysis

Riley E. Perszyk, Anders S. Kristensen, Polina Lyuboslavsky, +1

Genome Research

Hodgkin–Huxley–Katz Prize Lecture: Genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif

Riley E. Perszyk, Scott J. Myers, Hongjie Yuan, +4

The Journal of Physiology

GeneticsSynaptic TransmissionNeurotransmitterNeurotransmissionSynaptic Signaling +21

Classification of missense variants in the <i>N</i>-methyl-<scp>d</scp>-aspartate receptor <i>GRIN</i> gene family as gain- or loss-of-function

Scott J. Myers, Hongjie Yuan, Riley E. Perszyk, +9

Human Molecular Genetics

Nmdar-mediated Charge TransferGeneticsHuman PolymorphismMolecular BiologyNeurochemical Biomarkers +23

A novel class of negative allosteric modulators of NMDA receptor function

Brooke M. Katzman, Riley E. Perszyk, Hongjie Yuan, +4

Bioorganic & Medicinal Chemistry Letters

Negative Allosteric ModulatorsNmda Receptor FunctionBiochemistryFunctional SelectivityMedicine +8