Brian R. Hearn

Pharmacological brake-release of mRNA translation enhances cognitive memory

Carmela Sidrauski, Diego Acosta‐Alvear, Arkady Khoutorsky et al. · eLife · 2013 · 721 citations · Full text

Molecular Regulation, Conserved Mechanism, Initiation Factor 2 +17

USP7 small-molecule inhibitors interfere with ubiquitin binding

Lorna Kategaya, Paola Di Lello, Lionel Rougé et al. · Nature · 2017 · 332 citations · Full text

Molecular Docking, Ubiquitin Binding, Drug Target +7

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

Carmela Sidrauski, Jordan C. Tsai, Martin Kampmann et al. · eLife · 2015 · 260 citations · Full text

Exchange Factor Eif2b, Molecular Biology, Cell Culture +23

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

Ciara M Gallagher, Carolina Garri, Erica L. Cain et al. · eLife · 2016 · 198 citations · Full text

Pyrazole Amides, Molecular Biology, Cell Death +17

Predicting and Improving the Membrane Permeability of Peptidic Small Molecules

Salma B. Rafi, Brian R. Hearn, P. Vedantham et al. · Journal of Medicinal Chemistry · 2012 · 111 citations · Full text