Tarrick Qahash

The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple <i>Plasmodium</i> kinases and life cycle stages

Lauren B. Arendse, James M. Murithi, Tarrick Qahash et al. · Science Translational Medicine · 2022 · 46 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages

John Okombo, Sachel Mok, Tarrick Qahash et al. · PLoS Pathogens · 2022 · 28 citations · Full text

Veterinary Medicine, Infectious Diseases, Pharmacology +17

Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target

Eva S. Istvan, Francisco M. Guerra, Matthew Abraham et al. · Science Translational Medicine · 2023 · 27 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered <i>Plasmodium falciparum</i> physiology

Laura M. Hagenah, Satish K. Dhingra, Jennifer L. Small-Saunders et al. · mBio · 2023 · 17 citations · Full text

Life Sciences, Genetics, Infectious Diseases +17

Anti-inflammation and antimalarial profile of 5-pyridin-2-yl-1H-[1,2,4]triazole-3-carboxylic acid ethyl ester as a low molecular intermediate for hybrid drug synthesis

François Eya’ane Meva, Timothy J. Prior, David J. Evans et al. · Research on Chemical Intermediates · 2021 · 13 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11