Structural Basis of Selective Inhibition of Human Tankyrases

Mohit Narwal, Harikanth Venkannagari, L. Lehtiö

Journal of Medicinal Chemistry

Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage

Harikanth Venkannagari, Patricia Verheugd, Jarkko Koivunen, +7

Cell chemical biology

Dna DamageMedicineApoptosisOligonucleotideMolecular Biology +6

Discovery of Tankyrase Inhibiting Flavones with Increased Potency and Isoenzyme Selectivity

Mohit Narwal, Jarkko Koivunen, T. Haikarainen, +6

Journal of Medicinal Chemistry

Bioorganic ChemistryPharmaceutical ChemistryPolyphenolicsMedicinal ChemistryPhytopharmacology +17

Screening and Structural Analysis of Flavones Inhibiting Tankyrases

Mohit Narwal, T. Haikarainen, Adyary Fallarero, +2

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryNicotinamide Binding SiteMedicine +13

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

Lars Bräutigam, Linda Pudelko, Ann‐Sofie Jemth, +10

Cancer Research

Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors

T. Haikarainen, Mohit Narwal, Päivi Joensuu, +1

ACS Medicinal Chemistry Letters

Pharmaceutical ScienceBioorganic ChemistryAntiparasitic AgentChemical BiologyPharmaceutical Chemistry +15

Homogeneous Screening Assay for Human Tankyrase

Mohit Narwal, Adyary Fallarero, Pia Vuorela, +1

SLAS DISCOVERY

Drug TargetHuman Parp ProteinHomogeneous Screening AssayChemical BiologyEnzymatic Modification +14

<i>para</i>‐Substituted 2‐Phenyl‐3,4‐dihydroquinazolin‐4‐ones As Potent and Selective Tankyrase Inhibitors

T. Haikarainen, Jarkko Koivunen, Mohit Narwal, +5

ChemMedChem

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

Helen A. Paine, Amit Nathubhai, Esther C. Y. Woon, +9

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryNatural SciencesMedicineRational Drug Design +8

Structural Basis and Selectivity of Tankyrase Inhibition by a Wnt Signaling Inhibitor WIKI4

T. Haikarainen, Harikanth Venkannagari, Mohit Narwal, +4

PLoS ONE