The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation

Sara Carpi, Egeria Scoditti, Marika Massaro, +13

Nutrients

ImmunologyAdipokinesOxidative StressEvoo PolyphenolsInflammation +18

Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells

Stefano Fogli, Chiara Arena, Sara Carpi, +10

Nutrition and Cancer

Cutaneous Malignant MelanomaSkin CancerBiochemistryMedicinePhotocarcinogenesis +11

Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer

Beatrice Polini, Maria Digiacomo, Sara Carpi, +7

Toxicology in Vitro

OncologyNon-melanoma Skin CancerMedicinePhotocarcinogenesisAnti-cancer Agent +5

Identification of the First Synthetic Allosteric Modulator of the CB₂Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief

Francesca Gado, Lorenzo Di Cesare Mannelli, Elena Lucarini, +9

Journal of Medicinal Chemistry

Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease

Ziwei Chen, Maria Digiacomo, Yalin Tu, +12

European Journal of Medicinal Chemistry

Medicinal ChemistryAlzheimer's DiseaseBiochemistryMedicineMulti-targeted Agents +6

Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD

Maria Digiacomo, Ziwei Chen, Shengnan Wang, +7

Bioorganic & Medicinal Chemistry Letters

Multifunctional Tacrine DerivativesSeveral Disease PathwaysBiochemistryMedicineChemical Derivative +7

New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite:  Design, Synthesis, and Biopharmacological Properties

Maria Cristina Breschi, Vincenzo Calderone, Maria Digiacomo, +8

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceBiopharmacological PropertiesMedicineDrug Discovery +10

A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress

Laura Giusti, Cristina Angeloni, Maria Cristina Barbalace, +10

International Journal of Molecular Sciences

Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (<i>m</i>TAAR1) Agonists

Grazia Chiellini, Giulia Nesi, Maria Digiacomo, +12

Journal of Medicinal Chemistry

PharmacotherapyExperimental PharmacologyMolecular PharmacologyMedicinal ChemistryTaar1 Activation +15

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

Simona Sestito, Giulia Nesi, Simona Daniele, +12

European Journal of Medicinal Chemistry

Neuro-oncologyMedicinal ChemistryGliomaGlioblastoma MultiformeMedicine +8