Francesco DeGiacomo

Posttranslational Modification of Ataxin-7 at Lysine 257 Prevents Autophagy-Mediated Turnover of an N-Terminal Caspase-7 Cleavage Fragment

Shona A. Mookerjee, Theodora Papanikolaou, Stephan J. Guyenet et al. · Journal of Neuroscience · 2009 · 56 citations · Full text

Mitophagy, Prevents Autophagy-mediated Turnover, Ataxin-7 Protein +21

Identification and Evaluation of Small Molecule Pan-Caspase Inhibitors in Huntington's Disease Models

Melissa J. Leyva, Francesco DeGiacomo, Linda S. Kaltenbach et al. · Chemistry & Biology · 2010 · 54 citations

Disease Models, Medicine, Natural Sciences +6

Caspase-6 Activity in a BACHD Mouse Modulates Steady-State Levels of Mutant Huntingtin Protein But Is Not Necessary for Production of a 586 Amino Acid Proteolytic Fragment

Juliette Gafni, Theodora Papanikolaou, Francesco DeGiacomo et al. · Journal of Neuroscience · 2012 · 49 citations · Full text

A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease

John P. Miller, Bridget Yates, Ismael Al‐Ramahi et al. · PLoS Genetics · 2012 · 49 citations · Full text

Engineering, Mitochondrial Dysfunction, Genetics +21

Mass Spectrometric Identification of Novel Lysine Acetylation Sites in Huntingtin

Xin Cong, Jason M. Held, Francesco DeGiacomo et al. · Molecular & Cellular Proteomics · 2011 · 48 citations · Full text