Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Ulrika Tehler, Jonas H. Fagerberg, Richard Svensson, +3

Journal of Medicinal Chemistry

Pharmaceutical FormulationMedicinal ChemistryDrug AnalysisPharmaceutical ScienceMedicine +13

Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases

Martin Hemmerling, Stinabritt Nilsson, K. A. P. Edman, +27

Journal of Medicinal Chemistry

AsthmaInflammatory Lung DiseaseLung InflammationImmunologyPulmonary Diseases +18

Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery—A Particle Engineering Approach

Dariush Nikjoo, Irès van der Zwaan, Mikael Brűlls, +2

Pharmaceutics

Biopolymer GelHydrogelsHydrogels Warrant AttentionEngineeringBiomimetic Materials +10

Predicting Exposure After Oral Inhalation of the Selective Glucocorticoid Receptor Modulator, AZD5423, Based on Dose, Deposition Pattern, and Mechanistic Modeling of Pulmonary Disposition

Per Bäckman, Ulrika Tehler, Bo Olsson

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Ranking in Vitro Dissolution of Inhaled Micronized Drug Powders including a Candidate Drug with Two Different Particle Sizes

Frans Franek, Rebecca Fransson, Helena Thörn, +3

Molecular Pharmaceutics

iBCS: 2. Mechanistic Modeling of Pulmonary Availability of Inhaled Drugs versus Critical Product Attributes

Per Bäckman, Antonio Cabal, Carsten Ehrhardt, +12

Molecular Pharmaceutics

iBCS: 3. A Biopharmaceutics Classification System for Orally Inhaled Drug Products

Jayne E. Hastedt, Per Bäckman, Antonio Cabal, +12

Molecular Pharmaceutics

AsthmaIbcs ClassificationLung DepositionAllergyRespiratory Toxicology +10

Puromycin-sensitive aminopeptidase: An antiviral prodrug activating enzyme

Ulrika Tehler, Cara Nelson, Larryn W. Peterson, +5

Antiviral Research

PharmacologyAntiviral Drug DevelopmentAntiviral DrugPuromycin-sensitive Aminopeptidase

Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs

Göran Frenning, Irès van der Zwaan, Frans Franek, +2

Molecular Pharmaceutics

AZD5634, an inhaled ENaC inhibitor, in healthy subjects and patients with cystic fibrosis

Cecilia Kristensson, Annika Åstrand, Scott H. Donaldson, +13

Journal of Cystic Fibrosis