MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Helge Gad, Tobias Koolmeister, Ann‐Sofie Jemth, +54

Nature

Tumor BiologyDntp PoolMth1 InhibitionOncologyMedicine +6

Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development.

Paweł Baranczewski, Andrzej Stańczak, Kathrin Sundberg, +5

PubMed

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug–Drug Interactions

Maria Karlgren, Gustav Ahlin, Christel A. S. Bergström, +3

Pharmaceutical Research

RETRACTED: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

Satish Srinivas Kitambi, Enrique M. Toledo, Dmitry Usoskin, +19

Cell

Neuro-oncologyTumor InnervationMedicineCell DeathPathology +8

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Nadilly Bonagas, Nina Gustafsson, Martin Henriksson, +65

Nature Cancer

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Marcus J.G.W. Ladds, Ingeborg M.M. van Leeuwen, Catherine J. Drummond, +42

Nature Communications

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Björn Over, Patrick McCarren, Per Artursson, +12

Journal of Medicinal Chemistry

Pharmaceutical ScienceEngineeringPharmaceutical ChemistryMolecular PharmacologyMedicinal Chemistry +20

Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Sanjay R. Borhade, Richard Svensson, Peter Brandt, +3

ChemMedChem

Structure–Activity Relationships of Synthetic Cordycepin Analogues as Experimental Therapeutics for African Trypanosomiasis

Suman K. Vodnala, Thomas Lundbäck, Esther Yeheskieli, +8

Journal of Medicinal Chemistry

Bioorganic ChemistryAntiparasitic AgentChemical BiologyStructure–activity RelationshipsPharmaceutical Chemistry +15

Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Ulrika Tehler, Jonas H. Fagerberg, Richard Svensson, +3

Journal of Medicinal Chemistry

Pharmaceutical FormulationMedicinal ChemistryDrug AnalysisPharmaceutical ScienceMedicine +13