The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients

Anne Joutel, F. Andreux, Swann Gaulis, +7

Journal of Clinical Investigation

Notch3 Receptor AccumulatesAngiogenesisSignal TransductionEpendymaPathology +11

FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone

Simon Wöhrle, Olivier Bonny, Noémie Beluch, +11

Journal of Bone and Mineral Research

Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis

Fernanda do Valle Durães, Armelle Lafont, Martin Beibel, +12

JCI Insight

T-regulatory CellImmunologyImmune RegulationPathologyRegulatory T Cells +17

Characterization of the Mechanism of Action of the Pan Class I PI3K Inhibitor NVP-BKM120 across a Broad Range of Concentrations

Saskia M. Brachmann, Julia Kleylein-Sohn, Swann Gaulis, +20

Molecular Cancer Therapeutics

Cell DeathPi3k Inhibitor Nvp-bkm120Cancer BiologyTumor BiologyMicrotubule Dynamics +23

Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia

Caroline Dafflon, Vanessa J. Craig, Hélène Méreau, +17

Leukemia

Hematological MalignancyMedicineMixed-phenotype Acute LeukemiaMalignant Blood DisorderComplementary Activities +6

A distinct p53 target gene set predicts for response to the selective p53–HDM2 inhibitor NVP-CGM097

Sébastien Jeay, Swann Gaulis, Stéphane Ferretti, +18

eLife

Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53–MDM2 Inhibitor HDM201

Sébastien Jeay, Stéphane Ferretti, Philipp Holzer, +24

Cancer Research

PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

Melusine Bleu, Swann Gaulis, Rui Lopes, +16

Nature Communications

Demethylation of DNA by purified chick embryo 5-methylcytosine-DNA glycosylase requires both protein and RNA

Marc Frémont, Michel Siegmann, Swann Gaulis, +2

Nucleic Acids Research

-Dna GlycosylaseEpigenetic ChangeGeneticsDna MethylationMolecular Biology +16

Expression of defined genes identified by pretreatment tumor profiling: Association with clinical responses to the GSK MAGE- A3 immunotherapeutic in metastatic melanoma patients (EORTC 16032–18031)

Jamila Louahed, Olivier Gruselle, Swann Gaulis, +7

Journal of Clinical Oncology

Pretreatment Tumor ProfilingImmunologyImmunoeditingPathologyImmunotherapeutics +17