James McCabe

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

Ji Li, Ildiko Sarosi, Xiaoqiang Yan et al. · Proceedings of the National Academy of Sciences · 2000 · 1.1K citations

Medicine, Cell Biology, Genetics +17

Denosumab, a Fully Human Monoclonal Antibody to RANKL, Inhibits Bone Resorption and Increases BMD in Knock-In Mice That Express Chimeric (Murine/Human) RANKL

Paul J. Kostenuik, Hung Q. Nguyen, James McCabe et al. · Journal of Bone and Mineral Research · 2008 · 436 citations

Medicine, Immunology, Molecular Medicine +17

Antigen-specific human antibodies from mice comprising four distinct genetic modifications

Nils Lönberg, Lisa D. Taylor, Fiona Harding et al. · Nature · 1994 · 392 citations

Life Sciences, Immunology, Molecular Biology +14

Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody

Angela Coxon, James Bready, Hosung Min et al. · Molecular Cancer Therapeutics · 2010 · 149 citations · Full text

Medicine, Molecular Biology, Pharmacology +13

RANKL Inhibition with Osteoprotegerin Increases Bone Strength by Improving Cortical and Trabecular bone Architecture in Ovariectomized Rats

Michael S. Ominsky, Xiaodong Li, Frank Asuncion et al. · Journal of Bone and Mineral Research · 2008 · 129 citations

Medicine, Endocrinology, Orthopedic Surgery +17