Kouichi Sekiya

Carbon-carbon bond-forming reactions of zinc homoenolate of esters. A novel three-carbon nucleophile with general synthetic utility

Eiichi Nakamura, Satoshi Aoki, Kouichi Sekiya et al. · Journal of the American Chemical Society · 1987 · 244 citations

Natural Sciences, Chemistry, Catalysis +7

Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase.

Masanori Baba, Erik De Clercq, H. TANAKA et al. · Proceedings of the National Academy of Sciences · 1991 · 175 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents

Hiromichi Tanaka, Hideaki Takashima, Masaru Ubasawa et al. · Journal of Medicinal Chemistry · 1992 · 166 citations

Pharmacy, Medicinal Chemistry, Pharmacology +11

Synthesis and Antiviral Activity of 6-Benzyl Analogs of 1-[(2-Hydroxyethoxy)methyl]-5-(phenylthio)thymine (HEPT) as Potent and Selective Anti-HIV-1 Agents

Hiromichi Tanaka, Hideaki Takashima, Masaru Ubasawa et al. · Journal of Medicinal Chemistry · 1995 · 156 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9

Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogs: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity

Hiromichi Tanaka, Hideaki Takashima, Masaru Ubasawa et al. · Journal of Medicinal Chemistry · 1992 · 139 citations

Medicine, Chemistry, Pharmacology +15