Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs

Marc Hafner, Mario Niepel, Mirra Chung, +1

Nature Methods

MedicineEpidemiology Of CancerPharmacologyMetronomic TherapyCancer Drugs +8

Differential Transactivation by Two Isoforms of the Orphan Nuclear Hormone Receptor CAR

Hueng‐Sik Choi, Mirra Chung, Iphigenia Tzameli, +4

Journal of Biological Chemistry

Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity

Marc Hafner, Caitlin E. Mills, Kartik Subramanian, +8

Cell chemical biology

Drug TargetEngineeringTranslational BioinformaticsMedicinePharmacology +8

A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines

Mario Niepel, Marc Hafner, Caitlin E. Mills, +32

Cell Systems

Novel Receptor Interaction and Repression Domains in the Orphan Receptor SHP

Wongi Seol, Mirra Chung, David D. Moore

Molecular and Cellular Biology

A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb.

Bernard Dumas, Heather P. Harding, Hueng-Sik Choi, +4

Molecular Endocrinology

GeneticsMolecular BiologyBd73 Messenger RnaTranscriptional RegulationReceptor Tyrosine Kinase +18

Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling

Mario Niepel, Marc Hafner, Qiaonan Duan, +9

Nature Communications

Effective UseEngineeringTranscriptomics TechnologyGene Expression ProfilingTumor Biology +17

Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines

Mario Niepel, Marc Hafner, Emily A. Pace, +5

Science Signaling

Drug TargetBreast OncologyNew BiomarkersNetwork ActivityCell Signaling +16

Mice with a Targeted Deletion of the Type 2 Deiodinase Are Insulin Resistant and Susceptible to Diet Induced Obesity

Alessandro Marsili, Cristina Aguayo‐Mazzucato, Ting Chen, +12

PLoS ONE

Development and Characterization of a Wee1 Kinase Degrader

Zhengnian Li, Benika J. Pinch, Katherine A. Donovan, +9

Cell chemical biology

Cell DivisionReceptor Tyrosine KinaseProtein DegradationWee1 Kinase DegraderCell Cycle +4