Stuart J. Kemp

Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency

Ian R. Hardcastle, Junfeng Liu, Eric Valeur et al. · Journal of Medicinal Chemistry · 2011 · 149 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

Small-Molecule Inhibitors of the MDM2-p53 Protein−Protein Interaction Based on an Isoindolinone Scaffold

Ian R. Hardcastle, Shafiq U. Ahmed, Helen Atkins et al. · Journal of Medicinal Chemistry · 2006 · 147 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

Analysis of Chemical Shift Changes Reveals the Binding Modes of Isoindolinone Inhibitors of the MDM2-p53 Interaction

Christiane Riedinger, Jane Endicott, Stuart J. Kemp et al. · Journal of the American Chemical Society · 2008 · 112 citations

Medicine, Medicinal Chemistry, Pharmacology +12

Isoindolinone-based inhibitors of the MDM2–p53 protein–protein interaction

Ian R. Hardcastle, Shafiq U. Ahmed, Helen Atkins et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 91 citations

Medicine, Medicinal Chemistry, Oncology +9