Irina C. Jacobson

Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo

Chu‐Biao Xue, Matthew E. Voss, David J. Nelson et al. · Journal of Medicinal Chemistry · 2001 · 79 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Synthesis and preliminary evaluation of the fredericamycin A ABCDE ring system

Dale L. Boger, Irina C. Jacobson · The Journal of Organic Chemistry · 1991 · 42 citations

Natural Sciences, Chemistry, Medicinal Chemistry +5

Studies of the total synthesis of fredericamycin A. Preparation of key partial structures and development of an intermolecular alkyne-chromium carbene complex benzannulation cyclization approach to the ABCD(E) ring system

Dale L. Boger, Irina C. Jacobson · The Journal of Organic Chemistry · 1990 · 40 citations

Natural Sciences, Chemistry, Medicinal Chemistry +13

Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core

John M. Fevig, Donald Pinto, Qi Han et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases

Irina C. Jacobson, Prabhakar Reddy, Zelda R. Wasserman et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 27 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14