A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease

Salim S. Hayek, Kwi Hye Koh, Morgan E. Grams, +28

Nature Medicine

GlomerulonephritisApol1 Risk VariantsMedicineKidney FailureRenal Pathology +9

Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease

Eunsil Hahm, Changli Wei, Isabel Cuesta Fernández, +16

Nature Medicine

Main SourceUrologyBone Marrow FailureRenal FunctionKidney Research +7

Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models

Mario Schiffer, Beina Teng, Changkyu Gu, +22

Nature Medicine

Molecular PharmacologyUrologyRenal FunctionKidney ResearchMedicine +8

Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1

Ha Won Lee, Samia Q. Khan, Shehryar Khaliqdina, +17

Journal of Biological Chemistry

Comprehensive analysis of microRNA genomic loci identifies pervasive repetitive-element origins

Glen M. Borchert, Nathaniel W. Holton, Jonathan D. Williams, +18

Mobile Genetic Elements

Target MrnasTranscriptional RegulationGeneticsGene ExpressionComprehensive Analysis +10

uPAR isoform 2 forms a dimer and induces severe kidney disease in mice

Changli Wei, Jing Li, Brian D. Adair, +21

Journal of Clinical Investigation

Msupar2 SignalingRenal PathologyImmunologyRenal InflammationNephrology +25

A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules

Ha Won Lee, Samia Q. Khan, Mohd Hafeez Faridi, +9

Journal of the American Society of Nephrology

Immunocytochemical TechniqueImmunologyRenal InflammationCellular PharmacologyCytoskeleton +25

Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles

Kajal Gupta, Josef W. Goldufsky, Stephen Wood, +8

Developmental Cell

Cell PhysiologyCell RegulationApoptosisAutophagyCell Death +8

Nonimmune cell–derived ICOS ligand functions as a renoprotective αvβ3 integrin–selective antagonist

Kwi Hye Koh, Yanxia Cao, Steve Mangos, +12

Journal of Clinical Investigation

Icos Ligand FunctionsRenal PathologyImmune RegulationImmunologyRenal Inflammation +25

Inducible Protein Traps with Dominant Phenotypes for Functional Analysis of the<i>Drosophila</i>Genome

Swetha Singari, Naureen Javeed, Nicholas J. Tardi, +5

Genetics