Tom Owen‐Hughes

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

Patrick A. Grant, Laura J. Duggan, Jacques Côté et al. · Genes & Development · 1997 · 1.1K citations · Full text

Genetics, Molecular Biology, Molecular Genetics +21

How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?

Pietá Schofield, Marek Gierliński, Christian Cole et al. · RNA · 2016 · 930 citations · Full text

Engineering, Rna-seq Experiment, Genetics +23

The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

Craig A. Mizzen, Xiang‐Jiao Yang, Tetsuro Kokubo et al. · Cell · 1996 · 709 citations · Full text

Poly(ADP-ribose)–Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

Dragana Ahel, Zuzana Hořejšı́, Nicola Wiechens et al. · Science · 2009 · 586 citations · Full text

Histone Modifications, Chromatin, Genome Instability +15

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

William Farnaby, Manfred Koegl, Michael J. Roy et al. · Nature Chemical Biology · 2019 · 553 citations · Full text

Tumor Biology, Medicine, Natural Sciences +10