Laura Schäkel

Targeting the Main Protease of SARS‐CoV‐2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors

Julian Breidenbach, Carina Lemke, Thanigaimalai Pillaiyar et al. · Angewandte Chemie International Edition · 2021 · 148 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +16

3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents

Sho Konno, Kiyotaka Kobayashi, Miki Senda et al. · Journal of Medicinal Chemistry · 2021 · 129 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity

Shenghua Gao, Katharina Sylvester, Letian Song et al. · Journal of Medicinal Chemistry · 2022 · 83 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure–Activity Relationships, Antiviral Activity, and X-ray Structure Determination

Thanigaimalai Pillaiyar, Philipp Flury, Nadine Krüger et al. · Journal of Medicinal Chemistry · 2022 · 67 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors

Laura Schäkel, Constanze C. Schmies, Riham M. Idris et al. · Frontiers in Pharmacology · 2020 · 36 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15