Isabel Leung

De novo design of potent and selective mimics of IL-2 and IL-15

Daniel‐Adriano Silva, Shawn Yu, Umut Y. Ulge et al. · Nature · 2019 · 550 citations · Full text

Pharmacy, Immunology, Medicinal Chemistry +12

Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function

Alexander I. Salter, Anusha Rajan, Jacob J. Kennedy et al. · Science Signaling · 2021 · 163 citations · Full text

Life Sciences, Cell Biology, Immunology +17

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy

Alfredo Quijano‐Rubio, M. Aladdin Bhuiyan, Huilin Yang et al. · Nature Biotechnology · 2022 · 77 citations · Full text

Medicine, Immunology, Oncology +17

Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21

Isabel Leung, Ayelet Dekel, Julia M. Shifman et al. · Proceedings of the National Academy of Sciences · 2016 · 42 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

NOTCH1 signaling during CD4+ T-cell activation alters transcription factor networks and enhances antigen responsiveness

Alec B. Wilkens, Elena C. Fulton, Margot J. Pont et al. · Blood · 2022 · 26 citations · Full text

Life Sciences, Immunology, Molecular Biology +15