Benjamin J. Orlando

Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex

Minrui Fan, Jinru Zhang, Chen-Wei Tsai et al. · Nature · 2020 · 284 citations · Full text

Biochemistry, Mitochondrial Function, Natural Sciences +5

Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry

Michael J. Lucido, Benjamin J. Orlando, Alex J. Vecchio et al. · Biochemistry · 2016 · 228 citations · Full text

Crystal Structure, Medicinal Chemistry, Pharmaceutical Chemistry +14

Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone

Benjamin J. Orlando, Michael G. Malkowski · Journal of Biological Chemistry · 2016 · 221 citations · Full text

Biochemistry, Medicine, Lipid Peroxidation +7

ABCG2 transports anticancer drugs via a closed-to-open switch

Benjamin J. Orlando, Maofu Liao · Nature Communications · 2020 · 205 citations · Full text

Drug Target, Closed Conformation, Medicine +13

Crystal structure of rofecoxib bound to human cyclooxygenase-2

Benjamin J. Orlando, Michael G. Malkowski · Acta Crystallographica Section F Structural Biology Communications · 2016 · 173 citations · Full text

Methyl Sulfone Moiety, Medicinal Chemistry, Crystal Structure +14