The Design, Operation, and Application of a Dynamic Gastric Model

M. J. S. Wickham, Richard M. Faulks, James Mann, +1

Dissolution Technologies

In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration

James Butler, Bart Hens, Maria Vertzoni, +19

European Journal of Pharmaceutics and Biopharmaceutics

Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study

James Mann, Jennifer Dressman, Karin M. Rosenblatt, +17

Molecular Pharmaceutics

Pharmaceutical ScienceEngineeringGastroenterologyBiomedical EngineeringOrbito Study +16

Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine

W. Dieterle, Sophie Corynen, Sujata Vaidyanathan, +1

International Journal of Clinical Pharmacology and Therapeutics

Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations

Natalie Maclean, Erin Walsh, Mithushan Soundaranathan, +4

International Journal of Pharmaceutics

Direct Compression FormulationsEngineeringMicrofabricationCompression (Physics)Pharmaceutical Technology +2

Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part II. A mechanistic PBPK model for IR formulation comparison, proton pump inhibitor drug interactions, and administration with acidic juices

Xavier Pépin, Andrea Moir, James Mann, +10

European Journal of Pharmaceutics and Biopharmaceutics

Pharmaceutical ScienceVivo ExposureBiochemistryMedicineVitro Dissolution +5

Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part I. Mechanistic modelling of drug product dissolution to derive a P-PSD for PBPK model input

Xavier Pépin, Natalie Sanderson, Alexander Blanazs, +3

European Journal of Pharmaceutics and Biopharmaceutics

Vivo ExposureBiochemistryMedicineDrug Product DissolutionToxicology +4

Biorelevant dissolution testing of a weak base: Interlaboratory reproducibility and investigation of parameters controlling in vitro precipitation

Philippe Berben, L. J. Ashworth, Stefania Beato, +16

European Journal of Pharmaceutics and Biopharmaceutics

Biorelevant Dissolution TestingWeak BaseEngineeringEnvironmental EngineeringBioanalysis +5

Tablet disintegration performance: Effect of compression pressure and storage conditions on surface liquid absorption and swelling kinetics

Daniel Markl, Natalie Maclean, James Mann, +4

International Journal of Pharmaceutics

Materials ScienceDiffusion ResistanceLiquid-liquid FlowTablet Disintegration PerformanceSurface Liquid Absorption +1

Impact of Magnesium Stearate Presence and Variability on Drug Apparent Solubility Based on Drug Physicochemical Properties

Panagiota Zarmpi, Talia Flanagan, E. J. Meehan, +2

The AAPS Journal