Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity

Suzanne J. F. Kaptein, Sofie Jacobs, Lana Langendries, +32

Proceedings of the National Academy of Sciences

Antiviral CompoundEmerging Infectious DiseasesLacks ActivityHigh DoseMedicine +12

Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for <i>in Vivo</i> Dissolution and Absorption of Ionizable Drugs

Bart Hens, Yasuhiro Tsume, Marival Bermejo, +20

Molecular Pharmaceutics

Ibuprofen TabletHealthy SubjectsGastrointestinal PharmacologyGastroenterologyGi Tract +20

In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration

James Butler, Bart Hens, Maria Vertzoni, +19

European Journal of Pharmaceutics and Biopharmaceutics

Supersaturation and Precipitation of Posaconazole Upon Entry in the Upper Small Intestine in Humans

Bart Hens, Joachim Brouwers, Maura Corsetti, +1

Journal of Pharmaceutical Sciences

MedicineGastroenterologyMicrobiologyDigestive TractGut Barrier +3

Gastrointestinal behavior of nano- and microsized fenofibrate: In vivo evaluation in man and in vitro simulation by assessment of the permeation potential

Bart Hens, Joachim Brouwers, Maura Corsetti, +1

European Journal of Pharmaceutical Sciences

NanomedicineEngineeringMedicineFood DigestionGastroenterology +9

<i>In Silico</i> Modeling Approach for the Evaluation of Gastrointestinal Dissolution, Supersaturation, and Precipitation of Posaconazole

Bart Hens, Shriram M. Pathak, Amitava Mitra, +6

Molecular Pharmaceutics

Gastric DissolutionPharmacokinetic ModelingMedicineIdentical CsrPhysiology +12

Gastrointestinal transfer: In vivo evaluation and implementation in in vitro and in silico predictive tools

Bart Hens, Joachim Brouwers, Bart Anneveld, +6

European Journal of Pharmaceutical Sciences

Translational MedicineVivo EvaluationMedicinePhysiologyGastroenterology +6

A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

Marival Bermejo, Bart Hens, Joseph Dickens, +5

Pharmaceutics

Supersaturation in human gastric fluids

Jan Bevernage, Bart Hens, Joachim Brouwers, +3

European Journal of Pharmaceutics and Biopharmaceutics

Food DigestionPhysiologyGastroenterologyHuman Gastric FluidsDigestive Tract +2

Gastrointestinal and Systemic Monitoring of Posaconazole in Humans After Fasted and Fed State Administration of a Solid Dispersion

Bart Hens, Maura Corsetti, Joachim Brouwers, +1

Journal of Pharmaceutical Sciences

Fed State AdministrationMedicineSystemic MonitoringSolid DispersionDrug Monitoring +2