Jean‐Philippe Rocher

G-protein activation by a metabotropic glutamate receptor

Alpay B. Seven, Ximena Barros-Álvarez, Marine de Lapeyrière et al. · Nature · 2021 · 141 citations · Full text

Signal Transduction, G Protein-coupled Receptor, Medicine +5

Mechanism based neurotoxicity of mGlu5 positive allosteric modulators – Development challenges for a promising novel antipsychotic target

Sophie Parmentier‐Batteur, Peter H. Hutson, Karsten Menzel et al. · Neuropharmacology · 2013 · 93 citations

Molecular Pharmacology, Molecular Neuroscience, Development Challenges +11

Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1 <i>H</i> )-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

José M. Cid, Gary Tresadern, Guillaume Duvey et al. · Journal of Medicinal Chemistry · 2014 · 56 citations · Full text

Discovery of 1,4-Disubstituted 3-Cyano-2-pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

José M. Cid, Guillaume Duvey, Gary Tresadern et al. · Journal of Medicinal Chemistry · 2012 · 34 citations · Full text

Discovery of 1,5-Disubstituted Pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

José M. Cid, Guillaume Duvey, Philippe Cluzeau et al. · ACS Chemical Neuroscience · 2010 · 25 citations

Compound 8, High Throughput, Locomotor Activity +19