Paul Hemsley

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-<i>N</i>-methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

Jeffrey W. Johannes, Amber Balazs, Derek Barratt et al. · Journal of Medicinal Chemistry · 2021 · 140 citations · Full text

Life Sciences, Medicinal Chemistry, Oncology +13

Potent Reversible Inhibition of Myeloperoxidase by Aromatic Hydroxamates

Louisa V. Forbes, Tove Sjögren, Françoise Auchère et al. · Journal of Biological Chemistry · 2013 · 103 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +8

An evaluation of fluorescence polarization and lifetime discriminated polarization for high throughput screening of serine/threonine kinases

Ann Fowler, Denise Swift, Emma Longman et al. · Analytical Biochemistry · 2002 · 53 citations

Natural Sciences, Biochemistry, Molecular Biology +15

Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1

Joseph Shaw, Ian L. Dale, Paul Hemsley et al. · SLAS DISCOVERY · 2018 · 49 citations · Full text

Pharmacy, Biochemistry, Molecular Biology +15

The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger

K. A. P. Edman, Mark Furber, Paul Hemsley et al. · ChemMedChem · 2011 · 39 citations

Pharmacy, Chemistry, Medicinal Chemistry +14