Susan M. Cook

Evidence for a Significant Role of α3-Containing GABA_AReceptors in Mediating the Anxiolytic Effects of Benzodiazepines

Rebecca Dias, Wayne F. A. Sheppard, Rosa Fradley et al. · Journal of Neuroscience · 2005 · 244 citations · Full text

Anesthetic Mechanism, Psychopharmacology, Pharmacotherapy +19

TPA023 [7-(1,1-Dimethylethyl)-6-(2-ethyl-2 H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an Agonist Selective for α2- and α3-Containing GABAA Receptors, Is a Nonsedating Anxiolytic in Rodents and Primates

John Atack, Keith A. Wafford, Spencer J. Tye et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 187 citations

Identification of a Novel, Selective GABA_Aα5 Receptor Inverse Agonist Which Enhances Cognition

Mark S. Chambers, John Atack, Howard B. Broughton et al. · Journal of Medicinal Chemistry · 2003 · 140 citations · Full text

Neurotransmitter, Pharmacotherapy, Synaptic Signaling +22

3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-<i>a</i>]phthalazines and Analogues:  High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1

Robert W. Carling, Kevin W. Moore, Leslie J. Street et al. · Journal of Medicinal Chemistry · 2004 · 135 citations · Full text

Lead Identification, Organic Chemistry, Pharmacotherapy +18

Anxiogenic properties of an inverse agonist selective for <i>α</i>3 subunit‐containing GABA_A receptors

John Atack, Peter H. Hutson, Neil Collinson et al. · British Journal of Pharmacology · 2005 · 134 citations · Full text

Pharmacotherapy, Experimental Pharmacology, Molecular Pharmacology +17