Hideaki Natsugari

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-Butyl Ester)

Yuichi Morohashi, Toshiyuki Kan, Yusuke Tominari et al. · Journal of Biological Chemistry · 2006 · 184 citations · Full text

Sulindac Sulfide Is a Noncompetitive γ-Secretase Inhibitor That Preferentially Reduces Aβ42 Generation

Yasuko Takahashi, Ikuo Hayashi, Yusuke Tominari et al. · Journal of Biological Chemistry · 2003 · 179 citations · Full text

Axially Chiral 1,7-Naphthyridine-6-carboxamide Derivatives as Orally Active Tachykinin NK₁ Receptor Antagonists:  Synthesis, Antagonistic Activity, and Effects on Bladder Functions

Hideaki Natsugari, Yoshinori Ikeura, Izumi Kamo et al. · Journal of Medicinal Chemistry · 1999 · 97 citations · Full text

Beta-methyl Group, Chiral 1,7-Naphthyridine-6-carboxamide Derivatives, Cyclic Analogues +17

Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

Haruhiko Fuwa, Yasuko Takahashi, Yu Konno et al. · ACS Chemical Biology · 2007 · 90 citations

Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis

Keiki Kumano, Shigeo Masuda, Masataka Sata et al. · Pigment Cell & Melanoma Research · 2007 · 78 citations

Molecular Regulation, Adult Stem Cell, Melanocyte Homeostasis +19