Hirohiko Okamura

Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment

Takanori Eguchi, Chiharu Sogawa, Yuka Okusha et al. · PLoS ONE · 2018 · 133 citations · Full text

Engineering, Biological Microenvironments, Cell Culture +17

Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver

Mariko Seyama, Kaya Yoshida, Kayo Yoshida et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2020 · 127 citations

Outer Membrane Vesicles, Biochemistry, Physiology +4

Histone Demethylase Jmjd3 Regulates Osteoblast Differentiation via Transcription Factors Runx2 and Osterix

Di Yang, Hirohiko Okamura, Yoshiki Nakashima et al. · Journal of Biological Chemistry · 2013 · 110 citations · Full text

Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3β signaling pathway

Makoto Ishikawa, Kaya Yoshida, Hirohiko Okamura et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2013 · 110 citations

Signal Transduction, Akt/gsk-3β Signaling Pathway, Hepatic Glycogen Synthesis +7

Triple knockdown of CDC37, HSP90‐alpha and HSP90‐beta diminishes extracellular vesicles‐driven malignancy events and macrophage M2 polarization in oral cancer

Kisho Ono, Chiharu Sogawa, Hotaka Kawai et al. · Journal of Extracellular Vesicles · 2020 · 100 citations · Full text