Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment

Takanori Eguchi, Chiharu Sogawa, Yuka Okusha, +18

PLoS ONE

EngineeringBiological MicroenvironmentsCell CultureCell ProliferationCellular Aggregation +15

Triple knockdown of CDC37, HSP90‐alpha and HSP90‐beta diminishes extracellular vesicles‐driven malignancy events and macrophage M2 polarization in oral cancer

Kisho Ono, Chiharu Sogawa, Hotaka Kawai, +14

Journal of Extracellular Vesicles

Cell Stress Induced Stressome Release Including Damaged Membrane Vesicles and Extracellular HSP90 by Prostate Cancer Cells

Takanori Eguchi, Chiharu Sogawa, Kisho Ono, +6

Cells

Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells

Yuri Namba, Chiharu Sogawa, Yuka Okusha, +12

Frontiers in Oncology

Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles

Eman A. Taha, Chiharu Sogawa, Yuka Okusha, +9

Cancers

Mmp3-ko CellsExtracellular MicrovesiclesCancer BiologyTumor BiologyCancer Extracellular Vesicles +15

Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer

Yuka Okusha, Takanori Eguchi, Manh Tien Tran, +11

Cancers

Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3

Chiharu Sogawa, Takanori Eguchi, Manh Tien Tran, +11

Cancers

Circulating Tumor CellsCancer BiologyGliomaTumor BiologyOncology +16

The intranuclear PEX domain of MMP involves proliferation, migration, and metastasis of aggressive adenocarcinoma cells

Yuka Okusha, Takanori Eguchi, Chiharu Sogawa, +4

Journal of Cellular Biochemistry

Gel-Free 3D Tumoroids with Stem Cell Properties Modeling Drug Resistance to Cisplatin and Imatinib in Metastatic Colorectal Cancer

Chiharu Sogawa, Takanori Eguchi, Yuri Namba, +4

Cells

Ammonium tetrathiomolybdate enhances the antitumor effects of cetuximab via the suppression of osteoclastogenesis in head and neck squamous carcinoma

Ayaka Morisawa, Tatsuo Okui, Tsuyoshi Shimo, +6

International Journal of Oncology

Bone InvasionHnscc CellsAmmonium TetrathiomolybdateNeck Squamous CarcinomaRedox Biology +23