Ryan Greenwood

Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

Richard A. Ward, C. Brassington, Alexander L. Breeze et al. · Journal of Medicinal Chemistry · 2012 · 169 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +17

Reducing the Lipophilicity of Perfluoroalkyl Groups by CF₂–F/CF₂–Me or CF₃/CH₃ Exchange

Benjamin Jeffries, Zhong Wang, Jérôme Graton et al. · Journal of Medicinal Chemistry · 2018 · 112 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist

James S. Scott, Amber Balazs, Bernard Barlaam et al. · Journal of Medicinal Chemistry · 2020 · 111 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2

Richard A. Ward, Nicola Colclough, Mairi Challinor et al. · Journal of Medicinal Chemistry · 2015 · 105 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

A phase Ib dose-escalation study of the MEK inhibitor trametinib in combination with the PI3K/mTOR inhibitor GSK2126458 in patients with advanced solid tumors

Juneko E. Grilley‐Olson, Philippe L. Bédard, Angelica Fasolo et al. · Investigational New Drugs · 2016 · 80 citations · Full text

Medicine, Oncology, Pharmacology +15