Nigel J. Gooderham

CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans.

Alan R. Boobis, Anthony M. Lynch, Sandra Murray et al. · PubMed · 1994 · 261 citations

Medicine, Pharmacokinetics, Pharmacology +15

Polymorphisms in the cytochrome P450 CYP1A2 gene (<i>CYP1A2</i>) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism

Christoph Sachse, Upinder Bhambra, Gillian Smith et al. · British Journal of Clinical Pharmacology · 2003 · 173 citations · Full text

Medicine, Genetics, Oncology +16

Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef.

Anthony M. Lynch, Mark G. Knize, Alan R. Boobis et al. · PubMed · 1992 · 121 citations

Pharmacy, Pharmacology, Toxicology +11

Identification of Human Urinary Biomarkers of Cruciferous Vegetable Consumption by Metabonomic Profiling

William M. B. Edmands, Olaf Beckonert, Cinzia Stella et al. · Journal of Proteome Research · 2011 · 121 citations

Life Sciences, Nutrition, Nutritional Sciences +17

Quantification of the carcinogens 2-amino-3,8-dimethyl- and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in food using a combined assay based on gas chromatography—negative ion mass spectrometry

Stephen A. Murray, Anthony M. Lynch, Mark G. Knize et al. · Journal of Chromatography B Biomedical Sciences and Applications · 1993 · 114 citations

Pharmacy, Toxicology, Analytical Toxicology +7