Jonathan C. Chen

Engineered pegRNAs improve prime editing efficiency

James W. Nelson, Peyton B. Randolph, Simon P. Shen et al. · Nature Biotechnology · 2021 · 671 citations · Full text

Natural Sciences, Molecular Biology, Gene Editing +5

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness

Wei-Hsi Yeh, Olga Shubina-Oleinik, Jonathan M. Levy et al. · Science Translational Medicine · 2020 · 175 citations · Full text

Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis

Jeffrey C. Davis, Tiago C. Alves, Aharon Helman et al. · Cell Reports · 2020 · 132 citations · Full text

Metabolic Remodeling, Pancreas Transplantation, Insulin Signaling +19

Evolution of sequence-defined highly functionalized nucleic acid polymers

Zhen Chen, Phillip A. Lichtor, Adrian P. Berliner et al. · Nature Chemistry · 2018 · 110 citations · Full text

Nucleic Acid Chemistry, Engineering, Natural Sciences +9

Characterizing the in vivo role of trehalose in<i>Saccharomyces cerevisiae</i>using the<i>AGT1</i>transporter

Patrick A. Gibney, Ariel Schieler, Jonathan C. Chen et al. · Proceedings of the National Academy of Sciences · 2015 · 93 citations · Full text

Trehalose Pathway, Glycobiology, Molecular Biology +17