Hirofumi Hitomi

A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor–dependent pathway after renal injury in mice

Yifan Zhang, Daisuke Nakano, Yu Guan et al. · Kidney International · 2018 · 192 citations · Full text

Inflammation, Endothelial Cell Pathobiology, Renal Function +12

Renal Sympathetic Nerve Responses to Tempol in Spontaneously Hypertensive Rats

Takatomi Shokoji, Akira Nishiyama, Yoshihide Fujisawa et al. · Hypertension · 2003 · 146 citations

Hypertension, Redox Biology, Social Sciences +19

Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy

Kento Kitada, Daisuke Nakano, Hiroyuki Ohsaki et al. · Journal of Diabetes and its Complications · 2014 · 140 citations

Medicine, Physiology, Diabetes +9

Aldosterone Suppresses Insulin Signaling Via the Downregulation of Insulin Receptor Substrate-1 in Vascular Smooth Muscle Cells

Hirofumi Hitomi, Hideyasu Kiyomoto, Akira Nishiyama et al. · Hypertension · 2007 · 138 citations · Full text

Insulin Signaling, Oxidative Stress, Metabolic Syndrome +19

Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells

Yoshihiro Taniyama, Masuko Ushio‐Fukai, Hirofumi Hitomi et al. · American Journal of Physiology-Cell Physiology · 2004 · 125 citations

P38 Mapk Activity, P38 Mapk, Cardiovascular Function +18