Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development

Katherine A. Donovan, Fleur M. Ferguson, Jonathan W. Bushman, +31

Cell

Geometric ModelingRoboticsEngineeringExpedited Degrader DevelopmentNatural Sciences +9

A Small Molecule That Binds to an ATPase Domain of Hsc70 Promotes Membrane Trafficking of Mutant Cystic Fibrosis Transmembrane Conductance Regulator

Hyungseoph J. Cho, Heon Yung Gee, Kyung-Hwa Baek, +6

Journal of the American Chemical Society

Atpase DomainCystic Fibrosis CellsInflammatory Lung DiseaseMolecular RegulationMolecular Biology +17

Synthetic Small Molecules that Induce Neurogenesis in Skeletal Muscle

Darren R. Williams, Myung‐Ryul Lee, Young-Ah Song, +3

Journal of the American Chemical Society

Synthetic Small MoleculesMature Skeletal MuscleEngineeringMuscle FunctionCell Differentiation +17

Identification of Thieno[3,2-<i>d</i>]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3

Hanna Cho, Injae Shin, Hojong Yoon, +11

Journal of Medicinal Chemistry

A potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neurons

Beom Seok Kim, Chang‐Hee Lee, Gyeong-Eon Chang, +2

Scientific Reports

Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain

Duk-Joong Kim, Chang-Ki Choi, Chan-Soo Lee, +9

Experimental & Molecular Medicine

O-linked N-acetylglucosamine glycosylation of p65 aggravated the inflammation in both fibroblast-like synoviocytes stimulated by tumor necrosis factor-α and mice with collagen induced arthritis

Han Byeol Kim, Sang‐Won Lee, Chin Hee Mun, +6

Arthritis Research & Therapy

Raman-Based in Situ Monitoring of Changes in Molecular Signatures during Mitochondrially Mediated Apoptosis

Hyeon Jeong Shin, Ji Hye Lee, Yong Duk Kim, +3

ACS Omega

First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia

Hanna Cho, Injae Shin, Eunhye Ju, +8

Journal of Medicinal Chemistry

Chemoprevention StrategyMixed-phenotype Acute LeukemiaImmunologyMyeloid NeoplasiaHematological Malignancy +16

Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers

Seung-Hye Choi, SeongShick Ryu, Kyoungmi Sim, +6

European Journal of Medicinal Chemistry

Neuro-oncologyMedicinal ChemistryMedicinePharmacological AgentNeuroprotection +5