Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19

Sebastian J. Theobald, Alexander Simonis, Theodoros Georgomanolis, +30

EMBO Molecular Medicine

Inflammasome ActivationInnate Immune SystemViral PathogenesisImmunologyImmune Regulation +19

TNF-α-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer

Mengyu Tu, Lukas Klein, Elisa Espinet, +18

Nature Cancer

Pancreatic CancerMedicineSubtype IdentityImmunologyPathology +6

DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift

Julia Franzen, Theodoros Georgomanolis, Anton Selich, +15

Communications Biology

Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in <i>TP53</i>-deficient B-cell malignancies

Elena Izquierdo, Daniela Vorholt, Stuart J. Blakemore, +28

Blood

Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life

Jaco Selle, Katharina Dinger, Vanessa Jentgen, +23

Nature Communications

AsthmaSmc-specific AblationInflammatory Lung DiseaseLung InflammationImmunology +23

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

Malgorzata Gozdecka, Monika Dudek, Sean Wen, +39

Nature

BmCAP, a silkmoth gene encoding multiple protein isoforms characterized by SoHo and SH3 domains: Expression analysis during ovarian follicular development

Theodoros Georgomanolis, Kostas Iatrou, Luc Swevers

Insect Biochemistry and Molecular Biology

OocyteSilkmoth GeneMultiple Protein IsoformsDevelopmental BiologyCell Division +9

Monoallelic and biallelic variants in LEF1 are associated with a new syndrome combining ectodermal dysplasia and limb malformations caused by altered WNT signaling

William Dufour, Salem Alawbathani, Anne‐Sophie Jourdain, +22

Genetics in Medicine

Altered Wnt SignalingTranscriptional RegulationDevelopmental BiologyMendelian DisorderBiallelic Variants +7

NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition

Anna Juliane Vesting, Alexander Jaïs, Paul Klemm, +21

Molecular Metabolism

Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity

Janine Tutas, Marianna Tolve, Ebru Özer-Yildiz, +15

Nature Metabolism