Kathleen M. Ruppel

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

Robert L. Anderson, Darshan V. Trivedi, Saswata S. Sarkar et al. · Proceedings of the National Academy of Sciences · 2018 · 408 citations · Full text

Life Sciences, Biochemistry, Physiology +17

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Suman Nag, Darshan V. Trivedi, Saswata S. Sarkar et al. · Nature Structural & Molecular Biology · 2017 · 233 citations

Medicine, Cardiology, Genetics +13

Enzymatic activities correlate with chimaeric substitutions at the actin-binding face of myosin

Taro Q.P. Uyeda, Kathleen M. Ruppel, J A Spudich · Nature · 1994 · 205 citations

Life Sciences, Biochemistry, Molecular Biology +12

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function

Ruth F. Sommese, Jongmin Sung, Suman Nag et al. · Proceedings of the National Academy of Sciences · 2013 · 181 citations · Full text

Natural Sciences, Cardiology, Molecular Biology +16

Role of highly conserved lysine 130 of myosin motor domain. In vivo and in vitro characterization of site specifically mutated myosin.

Kathleen M. Ruppel, Taro Q.P. Uyeda, James A. Spudich · Journal of Biological Chemistry · 1994 · 145 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17