Sara L. Payne

Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency

Ian R. Hardcastle, Junfeng Liu, Eric Valeur et al. · Journal of Medicinal Chemistry · 2011 · 143 citations · Full text

Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer

Gary Beale, Emma J. Haagensen, Huw D. Thomas et al. · British Journal of Cancer · 2016 · 57 citations · Full text

Synthesis and biological evaluation of 5-substituted O4-alkylpyrimidines as CDK2 inhibitors

Francesco Marchetti, Céline Cano, Nicola J. Curtin et al. · Organic & Biomolecular Chemistry · 2010 · 28 citations

Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors

Sara L. Payne, Sonsoles Rodríguez-Arístegui, Julia Bárdos et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 20 citations · Full text

Isocoumarin-derived Inhibitors, Signal Transduction, Biochemistry +10

The Enhanced In Vivo Activity of the Combination of a MEK and a PI3K Inhibitor Correlates with [18F]-FLT PET in Human Colorectal Cancer Xenograft Tumour-Bearing Mice

Emma J. Haagensen, Huw D. Thomas, Ian A. Wilson et al. · PLoS ONE · 2013 · 13 citations · Full text

Combined Pi3k, Chemoprevention Strategy, Pathology +17