Cristiana O’Brien

The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness

Geethu Emily Thomas, Grace Egan, Laura García‐Prat et al. · Nature Cell Biology · 2022 · 82 citations · Full text

Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity

Cristiana O’Brien, Tianyi Ling, Jacob M. Berman et al. · Haematologica · 2023 · 22 citations · Full text

Lipid Peroxidation, Metabolic Remodeling, Sirtuin 3 +19

Quantitative intravital imaging for real-time monitoring of pancreatic tumor cell hypoxia and stroma in an orthotopic mouse model

Timothy Samuel, Sara Rapic, Cristiana O’Brien et al. · Science Advances · 2023 · 16 citations · Full text

Real-time Monitoring, Biological Microenvironments, Cancer Biology +18

Oligomerization and the Affinity of Maize Phosphoenolpyruvate Carboxylase for Its Substrate

Randolph T. Wedding, Cristiana O’Brien, Katie Kline · PLANT PHYSIOLOGY · 1994 · 13 citations · Full text

Plant Physiology, Molecular Biology, Tetrameric Form +17

Enriching for human acute myeloid leukemia stem cells using reactive oxygen species-based cell sorting

Brett M. Stevens, Cristiana O’Brien, Craig T. Jordan et al. · STAR Protocols · 2020 · 12 citations · Full text

Mixed-phenotype Acute Leukemia, Immunology, Blood Cell +16