Apelin-APJ Signaling Is a Critical Regulator of Endothelial MEF2 Activation in Cardiovascular Development

Yujung Kang, Jongmin Kim, Joshua P. Anderson, +10

Circulation Research

Aldose Reductase–Mediated Phosphorylation of p53 Leads to Mitochondrial Dysfunction and Damage in Diabetic Platelets

Wai Ho Tang, Jeremiah Stitham, Jin Yu, +8

Circulation

Acceleration of Cardiovascular Disease by a Dysfunctional Prostacyclin Receptor Mutation

Eric Arehart, Jeremiah Stitham, Folkert W. Asselbergs, +16

Circulation Research

Heart FailureVascular DiseaseImmunologyCardiovascular PharmacologyPathology +20

Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane

Wai Ho Tang, Jeremiah Stitham, Scott Gleim, +13

Journal of Clinical Investigation

Platelet AggregationOxidative StressMetabolic SyndromeThrombosisHematology +22

CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

Nathan T. Ross, Felix Lohmann, Seth Carbonneau, +39

Nature Chemical Biology

Transcriptional RegulationMedicineCancer Cell BiologyDruggable NodeCpsf3-dependent Pre-mrna Processing +7

DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

Martin Schröder, Martin Renatus, Xiaoyou Liang, +37

Nature Communications

Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition

Yi Xie, Jin Yu, Bethany L. Merenick, +17

Science Signaling

Application of Large-Scale Aptamer-Based Proteomic Profiling to Planned Myocardial Infarctions

Jaison Jacob, Debby Ngo, Nancy Finkel, +8

Circulation

BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma

Ellen Weisberg, Basudev Chowdhury, Chengcheng Meng, +30

Blood Cancer Journal

Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study

Paola Patrignani, Concetta Di Febbo, Stefania Tacconelli, +13

Pharmacogenetics and Genomics

Vascular DiseasePtgir PolymorphismsImmunologyGenetic EpidemiologyPathology +21