Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease

Hao Lu, Maria C. Rondón Galeano, Elisabeth Ott, +30

Nature Genetics

Mendelian DisorderGenetic DisorderGeneticsInherited Metabolic DiseaseRenal Pathology +6

Nervous System Regionalization Entails Axial Allocation before Neural Differentiation

Vicki Metzis, Sebastian Steinhauser, Edvinas Pakanavicius, +9

Cell

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells

Leona Gabryšová, Marisol Alvarez-Martinez, Raphaëlle Luisier, +18

Nature Immunology

InflammationSystems BiologyAutoimmune DiseaseAdaptive Immune SystemT-regulatory Cell +12

Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation

Robert Blassberg, Harshil Patel, Thomas Watson, +4

Nature Cell Biology

Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks

Katherine Exelby, Edgar Herrera-Delgado, Lorena Garcia Perez, +5

Development

Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb

Natalie C. Butterfield, Vicki Metzis, Edwina McGlinn, +3

Development

Lineage PlasticityCell LineageDevelopmental BiologySignal TransductionVertebrate Hedgehog Receptor +13

Patched1 is required in neural crest cells for the prevention of orofacial clefts

Vicki Metzis, Andrew D. Courtney, Markus C. Kerr, +5

Human Molecular Genetics

Conditional LossNeural Crest CellsGeneticsNeural Stem CellEpigenetics +18

Inactivation of Patched1 in the Mouse Limb Has Novel Inhibitory Effects on the Chondrogenic Program

Stephen J. Bruce, Natalie C. Butterfield, Vicki Metzis, +3

Journal of Biological Chemistry

ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex

Claudia I. Semprich, L. S. P. Davidson, A. A. G. Torres, +4

PLoS Biology

ChromatinChromatin OrganizationDevelopmental BiologyChromatin StructureSignaling Pathway +13

Expression of the NET family member <i>Zfp503</i> is regulated by hedgehog and BMP signaling in the limb

Edwina McGlinn, Joy M. Richman, Vicki Metzis, +4

Developmental Dynamics