Molecular Determinants of Vanilloid Sensitivity in TRPV1

Narender R. Gavva, Lana Klionsky, Yusheng Qu, +15

Journal of Biological Chemistry

<i>N</i>-(3-Acyloxy-2-benzylpropyl)-<i>N</i>‘-[4-(methylsulfonylamino)benzyl]thiourea Analogues:  Novel Potent and High Affinity Antagonists and Partial Antagonists of the Vanilloid Receptor

Jeewoo Lee, Jiyoun Lee, Myungshim Kang, +18

Journal of Medicinal Chemistry

Structural Insight into Tetrameric hTRPV1 from Homology Modeling, Molecular Docking, Molecular Dynamics Simulation, Virtual Screening, and Bioassay Validations

Zhiwei Feng, Larry V. Pearce, Xiaomeng Xu, +4

Journal of Chemical Information and Modeling

EngineeringStructural BioinformaticsBiomolecular Structure PredictionMolecular BiologyStructural Insight +16

Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies

Jin Hee Lee, Yoonji Lee, HyungChul Ryu, +7

Journal of Computer-Aided Molecular Design

Signal TransductionG Protein-coupled ReceptorFlexible DockingMedicineFunctional Selectivity +8

Evodiamine functions as an agonist for the vanilloid receptor TRPV1

Larry V. Pearce, Pavel A. Petukhov, Tamás Szabó, +4

Organic & Biomolecular Chemistry

Molecular BiologyEvodiamine FunctionsPharmacotherapyExperimental PharmacologyMolecular Pharmacology +16

Engineering vanilloid-sensitivity into the rat TRPV2 channel

Feng Zhang, Sonya M. Hanson, Andrés Jara-Oseguera, +6

eLife

Proteinlipid InteractionMolecular BiologyNeurotransmissionAnalytical UltracentrifugationBiophysics +18

Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1

Attila Tóth, Yun Wang, Noémi Kedei, +7

Life Sciences

2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as Potent Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists: Structure–Activity Relationships of 2-Amino Derivatives in the<i>N</i>-(6-Trifluoromethylpyridin-3-ylmethyl) C-Region

Myeong Seop Kim, HyungChul Ryu, Dong Wook Kang, +21

Journal of Medicinal Chemistry

N-[4-(Methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure–activity relationships for the ‘C-Region’

Jeewoo Lee, Sang-Uk Kang, Ju‐Ok Lim, +8

Bioorganic & Medicinal Chemistry

Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain

Hobin Lee, Songyeon Ahn, Jihyae Ann, +11

European Journal of Medicinal Chemistry

Pain TherapyHealth SciencesMedicinePain MedicineTrpv1 Antagonists +10