Rachel E. Davis

A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors

Jia Zhou, Camille Gelot, Constantia Pantelidou et al. · Nature Cancer · 2021 · 337 citations · Full text

Life Sciences, Molecular Biology, Oncology +11

6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity

Hwei‐Ru Tsou, Nellie Mamuya, Bernard D. Johnson et al. · Journal of Medicinal Chemistry · 2001 · 274 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Synthesis and Structure−Activity Relationships of 6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2)

Allan Wissner, Elsebe Overbeek, Marvin F. Reich et al. · Journal of Medicinal Chemistry · 2002 · 266 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer

James P. O’Connell, John Porter, Boris Kroeplien et al. · Nature Communications · 2019 · 131 citations · Full text

Medicine, Immunology, Pharmacology +12

Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

David McMillan, C. Martinez-Fleites, John Porter et al. · Nature Communications · 2021 · 90 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +15