John Isbell

Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents

Tao Wu, A. S. Nagle, Kelli Kuhen et al. · Journal of Medicinal Chemistry · 2011 · 104 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of (<i>R</i>,<i>E</i>)-<i>N</i>-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1<i>H</i>-benzo[<i>d</i>]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers

G. Lelais, Robert Epple, Thomas H. Marsilje et al. · Journal of Medicinal Chemistry · 2016 · 95 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents

A. S. Nagle, Tao Wu, Kelli Kuhen et al. · Journal of Medicinal Chemistry · 2012 · 93 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Enhanced in-Source Fragmentation Annotation Enables Novel Data Independent Acquisition and Autonomous METLIN Molecular Identification

Jingchuan Xue, Xavier Domingo-Almenara, Carlos Guijas et al. · Analytical Chemistry · 2020 · 64 citations · Full text

Natural Sciences, Biochemistry, Analytical Chemistry +14

Realities of High-Throughput Liquid Chromatography/Mass Spectrometry Purification of Large Combinatorial Libraries:  A Report on Overall Sample Throughput Using Parallel Purification

John Isbell, Rongda Xu, Zekun Cai et al. · Journal of Combinatorial Chemistry · 2002 · 44 citations

Pharmacy, Chemistry, Analytical Chemistry +16