Discovery of Alogliptin:  A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV

Jun Feng, Zhiyuan Zhang, Michael B. Wallace, +11

Journal of Medicinal Chemistry

Plasma Dpp-4 ActivityPharmacotherapyChemical BiologyPharmaceutical ChemistryMedicinal Chemistry +15

Oxidative conjugation of catechols with proteins in insect skeletal systems

Karl J. Kramer, Michael R. Kanost, Theodore L. Hopkins, +5

Tetrahedron

BiotransformationAldehyde DehydrogenaseBiochemistryNatural SciencesBiocatalysis +4

Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV

Zhiyuan Zhang, Michael B. Wallace, Jun Feng, +12

Journal of Medicinal Chemistry

Pharmaceutical SciencePlasma Dpp-4 ActivityPharmacotherapyPharmaceutical ChemistryPyrimidinedione Inhibitors +14

Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries

Kelly M. Jenkins, Reginald Angeles, Marianne T. Quintos, +3

Journal of Pharmaceutical and Biomedical Analysis

Metabolic StabilityBiochemistryCombinatorial LibrariesMedicineBioanalysis +9

AC0010, an Irreversible EGFR Inhibitor Selectively Targeting Mutated EGFR and Overcoming T790M-Induced Resistance in Animal Models and Lung Cancer Patients

Xiao Xu, Long Mao, Wanhong Xu, +12

Molecular Cancer Therapeutics

ImmunologyPathologyPharmacotherapyCancer BiologyTumor Biology +19

Application of parallel liquid chromatography/mass spectrometry for high throughput microsomal stability screening of compound libraries

Rongda Xu, Csaba Nemes, Kelly M. Jenkins, +3

Journal of the American Society for Mass Spectrometry

High ThroughputMetabolomic ProfilingGas ChromatographyBioanalysisAnalytical Chemistry +15

Benzoquinone levels as a function of age and gender of the red flour beetle, Tribolium castaneum

Lisa M Unruh, Rongda Xu, Karl J. Kramer

Insect Biochemistry and Molecular Biology

BiologyTribolium CastaneumPesticide ResistanceEntomologyRed Flour Beetle +4

Catecholamine and histidyl protein cross-linked structures in sclerotized insect cuticle

Rongda Xu

Insect Biochemistry and Molecular Biology

BiologySclerotized Insect CuticleNatural SciencesEntomologyMolecular Biology +5

Mass Spectrometric Analysis of Catechol–Histidine Adducts from Insect Cuticle

James L. Kerwin, František Tureček, Rongda Xu, +4

Analytical Biochemistry

BiochemistryGas ChromatographyNatural SciencesMass SpectrometryBiological Mass Spectrometry +2

Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors

Michael B. Wallace, Jun Feng, Zhiyuan Zhang, +6

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBiochemistryBenzimidazole DerivativesNatural Sciences +8