Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

Yaron Pereg, Dganit Shkedy, Petra de Graaf, +8

Proceedings of the National Academy of Sciences

DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

Koji Okamoto, Kenji Kashima, Yaron Pereg, +11

Molecular and Cellular Biology

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A

Yaron Pereg, Bob Y. Liu, Karen O’Rourke, +5

Nature Cell Biology

Natural SciencesMolecular BiologyGene RegulationUbiquitin Hydrolase Dub3Gene Expression

The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression

Michal Abraham, Shiri Klein, Baruch Bulvik, +14

Leukemia

MedicineApoptosisImmunologyAml BlastsCell Death +6

Dual targeting of the protein disulfide isomerase RB60 to the chloroplast and the endoplasmic reticulum

Alexander Levitan, Tova Trebitsh, Vladimir Kiss, +3

Proceedings of the National Academy of Sciences

Differential Roles of ATM- and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage

Yaron Pereg, Suzanne Lam, Amina F.A.S. Teunisse, +8

Molecular and Cellular Biology

Dna DamageMolecular BiologyCell DeathCell CycleDifferential Roles +19

Nuclear Ataxia-Telangiectasia Mutated (ATM) Mediates the Cellular Response to DNA Double Strand Breaks in Human Neuron-like Cells

Sharon Biton, Inbal Dar, Leonid Mittelman, +3

Journal of Biological Chemistry

Dna DamageGeneticsGenomic MechanismCell DeathNuclear Atm +14

CXCR4 Promotes Neuroblastoma Growth and Therapeutic Resistance through miR-15a/16-1–Mediated ERK and BCL2/Cyclin D1 Pathways

Shiri Klein, Michal Abraham, Baruch Bulvik, +14

Cancer Research

Single Dose of the CXCR4 Antagonist BL-8040 Induces Rapid Mobilization for the Collection of Human CD34+ Cells in Healthy Volunteers

Michal Abraham, Yaron Pereg, Baruch Bulvik, +13

Clinical Cancer Research

ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells

Sharon Biton, Michal Gropp, Pavel Itsykson, +5

DNA repair

Human NeuronsGenome InstabilityDevelopmental BiologyMedicineAdult Stem Cell +7