Andreas Mühlemann

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

Richard H. Porter, Georg Jaeschke, Will Spooren et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 314 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP

Pari Malherbe, Nicole A. Kratochwil, Andreas Mühlemann et al. · Journal of Neurochemistry · 2006 · 69 citations

Medicine, Medicinal Chemistry, Pharmacology +17

An Automated System for the Analysis of G Protein-Coupled Receptor Transmembrane Binding Pockets:  Alignment, Receptor-Based Pharmacophores, and Their Application

Nicole A. Kratochwil, Pari Malherbe, Lothar Lindemann et al. · Journal of Chemical Information and Modeling · 2005 · 59 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Determination of key amino acids implicated in the actions of allosteric modulation by 3,3′-difluorobenzaldazine on rat mGlu5 receptors

Andreas Mühlemann, Natalie A. Ward, Nicole A. Kratochwil et al. · European Journal of Pharmacology · 2005 · 56 citations

Medicine, Neuroscience, Pharmacology +15

Glucosylceramide synthase inhibition with lucerastat lowers globotriaosylceramide and lysosome staining in cultured fibroblasts from Fabry patients with different mutation types

Richard W.D. Welford, Andreas Mühlemann, Marco Garzotti et al. · Human Molecular Genetics · 2018 · 43 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16