Clinton J. Bradfield

Interferon-induced guanylate-binding proteins in inflammasome activation and host defense

Bae-Hoon Kim, Jonathan Chee, Clinton J. Bradfield et al. · Nature Immunology · 2016 · 154 citations · Full text

Inflammation, Innate Immune System, Immunology +6

IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages

Sinu P. John, Jing Sun, Rebecca J. Carlson et al. · Cell Reports · 2018 · 109 citations · Full text

A human apolipoprotein L with detergent-like activity kills intracellular pathogens

Ryan G. Gaudet, Shiwei Zhu, Anushka Halder et al. · Science · 2021 · 101 citations · Full text

Microbial Pathogens, Innate Immune System, Immunology +26

Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection

Shiwei Zhu, Clinton J. Bradfield, Agnieszka Mamińska et al. · Science · 2024 · 41 citations · Full text

Protein Assembly, Microbial Pathogens, Innate Immune System +16

Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis

Clinton J. Bradfield, J. Liang, Orna Ernst et al. · Cell Death and Differentiation · 2023 · 32 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +10