Brian B. Lee

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Publications

Citations

1.1K

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Active since

2008

Affiliations

Array BioPharma (United States)(Current)

Brian B. Lee is an author at Array BioPharma (United States) specializing in phosphatidylinositol 3-kinase-akt signaling, phosphatidylinositol 3-kinase-akt pathway, and pi3 kinase-akt signaling.

Publications per year

2008–2013

Publications

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

Michael Degtyarev, Ann De Mazière, Christine Orr et al. · The Journal of Cell Biology · 2008 · 410 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models

Jie Lin, Deepak Sampath, Michelle Nannini et al. · Clinical Cancer Research · 2013 · 295 citations

Medicine, Oncology, Pharmacology +16

Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

James F. Blake, Rui Xu, Josef R. Bencsik et al. · Journal of Medicinal Chemistry · 2012 · 188 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

Kui Lin, Jie Lin, Wen‐I Wu et al. · Science Signaling · 2012 · 171 citations

Life Sciences, Biochemistry, Molecular Biology +17

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