Hein te Riele

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

Niels de Wind, Marleen Dekker, Anton Berns et al. · Cell · 1995 · 792 citations · Full text

Knockout Mouse, Genome Instability, Somatic Variant +8

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.

N M van der Lugt, Jos Domen, Koert Linders et al. · Genes & Development · 1994 · 778 citations · Full text

Bmi-1 Gene, B-cell Lymphomagenesis, Genetics +19

An HMG-box-containing T-cell factor required for thymocyte differentiation

Sjef Verbeek, David J. Izon, Frans M.A. Hofhuis et al. · Nature · 1995 · 512 citations · Full text

Lymphocyte Development, T-regulatory Cell, Immunology +5

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs.

Hein te Riele, Els Robanus Maandag, Anton Berns · Proceedings of the National Academy of Sciences · 1992 · 444 citations · Full text

Genetics, Isogenic Dna Constructs, Gene Delivery +18

Inducing and exploiting vulnerabilities for the treatment of liver cancer

Cun Wang, Serena Vegna, Haojie Jin et al. · Nature · 2019 · 417 citations

Translational Medicine, Hepatology, Medicine +9