Marissa Coffils

SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity

John A. Hartley, Anzu Hamaguchi, Marissa Coffils et al. · Cancer Research · 2010 · 59 citations · Full text

Drug Target, Chemoprevention Strategy, Molecular Biology +16

Structure−Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-<i>c</i>][1,4]benzodiazepine (PBD) Antitumor Agents

Dyeison Antonow, Maciej Kaliszczak, Gyoung‐Dong Kang et al. · Journal of Medicinal Chemistry · 2010 · 40 citations

Medicinal Chemistry, Medicine, Structure−activity Relationships +15

Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate

Philip W. Howard, Zhizhi Chen, Stephen J. Gregson et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 33 citations

Medicinal Chemistry, Natural Sciences, Medicine +7

Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: Synthesis, DNA interaction, cytotoxicity and differential cellular localization

Geoffrey Wells, Marie Suggitt, Marissa Coffils et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 31 citations

Medicine, Natural Sciences, Molecular Biology +7